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Image Search Results
Journal: Neurobiology of disease
Article Title: TDP-43 expression influences amyloid β plaque deposition and tau aggregation
doi: 10.1016/j.nbd.2017.04.012
Figure Lengend Snippet: A) Western blots for APP/PS1 and wildtype primary cortical neurons infected with human TDP-43 virus. B) Western blot of calcineurin expression in HEK293T cells transfected with either non-targeting siRNA (siNC) or siTDP-43. Knockdown of TDP-43 increased calcineurin expression. C and D) Quantitation of normalized calcineurin expression by Western blots in A and B, respectively. *p<0.05, **p<0.001, One-way ANOVA with Bonferroni multiple comparison correction was performed for A. Student t-tests was performed for B. E) Phosphorylated TDP-43(Ser409/410) was more prevalent in Camk2a/hTDP-43/APP/PS1 mice but also observed in APP/PS1 mice. Arrows indicate cytoplasmic accumulation of diffuse endogenous phosphorylated TDP-43(S409/410) (phospho-TDP, Cosmobio, green; TDP-43, Genscript, red; DAPI, blue) 1000X magnification.
Article Snippet: Data analyses were performed using a one or two-way ANOVA with
Techniques: Western Blot, Infection, Virus, Expressing, Transfection, Knockdown, Quantitation Assay, Comparison